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Problem 4: The elimination half-life of tobramycin was repor

Problem 4: The elimination half-life of tobramycin was repor

Problem 4: The elimination half-life of tobramycin was reportedto be 2.15 hours and the Vd was reported to be 33.5%of body weight. Assume that the drug is given byintravenous bolus injection every 8 hours. a. What is the dose for an 80kg individual if aaverage steady-state level of 2.5 mg/L is desired? b. Explain what will be the consequence if patientdevelop kidney or hepatic dysfunction. Problem 5: The manufacturer has suggested that in normalcases, tobramycin should be given at a rate of 1mg/kg every 8 hours. With this dosage regimenfor the same patient at problem 4, a. What would be the plasma average steady state level?

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